LC10

Formulation: A solution in ethanol

Formal Name: (R)-N-(2-(didecylamino)ethyl)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamide

Purity: ≥98%

Formula Markup: C46H86N2O2 • HCl

Formula Weight: 735,7

Shelf life (days): 365

Notes: LC10 is a lipidoid derivative of the secondary bile acid lithocholic acid (Item No. 20253) that contains two 10-carbon alkyl chains.{66148} It has been used in the generation of self-assembling skin-permeable lipid nanoparticles (LNPs). LC10 LNPs inhibit the proliferation of normal human epidermal keratinocytes (NHEKs) when used at a concentration of 100 nM and reduce the levels of TNF-α, IL-17, and IL-23 in human peripheral blood mononuclear cells (PBMCs) at 50, 100, and 200 nM. Topical application of LC10 LNPs (10 mg/kg) reduces psoriatic-like plaques and reverses weight loss induced by imiquimod (Item No. 14956) in a mouse model of psoriasis.

• Artikelnummer: CAY37000-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37000-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: Reinstoffe