Lipid CL1, CAS 1450888-71-7

Formulation: A solution in ethanol

Formal Name: 5-(dimethylamino)-pentanoic acid, (6Z)-1,2-di-(4Z)-4-decen-1-yl-6-dodecen-1-yl ester

Purity: ≥95%

Formula Markup: C39H73NO2

Formula Weight: 588

Shelf life (days): 365

CAS Number: 1450888-71-7

Notes: Lipid CL1 is an ionizable cationic trialkyl lipid (pKa = 6.3) that has been used in the formation of lipid nanoparticles (LNPs) for delivering mRNA in vivo.{72476,64931} LNPs containing lipid CL1 and encapsulating mRNA encoding human erythropoietin (EPO) increase blood EPO protein levels in mice.{64931} LNPs containing lipid CL1 and encapsulating mRNA encoding a reporter protein increase reporter expression in the liver to a greater extent than LNPs containing the ionizable lipids DLin-DMA (Item No. 36701), KC2 (DLin-KC2-DMA; Item No. 34363), MC3 (DLin-MC3-DMA; Item No. 34364), or LP-01 (Item No. 37278) in mice.{72476} LNPs containing lipid CL1 and encapsulating mRNA encoding influenza A hemagglutinin (HA) increase anti-HA IgG antibody titers to a greater extent than LNPs containing the ionizable cationic lipid SM-102 (Item No. 33474) in a mouse model of HA vaccination.

• Artikelnummer: CAY38320-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38320-50
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK