Lipid 14, CAS 2430034-05-0

Formulation: A solution in methyl acetate

Formal Name: ((2-((4-(dimethylamino)butanoyl)oxy)ethyl)azanediyl)bis(octane-8,1-diyl) bis(2-hexyldecanoate)

Purity: ≥95%

Formula Markup: C56H110N2O6

Formula Weight: 907,5

Shelf life (days): 730

CAS Number: 2430034-05-0

Notes: Lipid 14 is an ionizable cationic amino lipid that has been used in the formation of lipid nanoparticles (LNPs).{67335} LNPs containing lipid 14 and encapsulating mRNA encoding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein receptor-binding domain (RBD), also known as the surface glycoprotein RBD, increase anti-RBD antibody levels in mice, as well as increase the number of isolated mouse splenocytes secreting IFN-γ and IL-2, but not IL-4 or IL-10, when incubated with the SARS-CoV-2 spike glycoprotein. LNPs containing lipid 14 and encapsulating mRNA encoding the bacterial Caf1 (F1) capsule antigen from Y. pestis, the bacteria that causes bubonic plague, induces anti-F1 cellular and humoral responses and protects against lethal Y. pestis infection in mice.{67277}

• Artikelnummer: CAY38589-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38589-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe