Lipid 331

Formulation: A solution in ethanol

Formal Name: di((9Z,12Z)-octadeca-9,12-dien-1-yl) 4,4'-(2-(tert-butoxycarbonyl)-1-(2-(2-ethylpiperidin-1-yl)ethyl)-2,5-dihydro-1H-imidazole-5,5-diyl)dibutyrate

Purity: ≥95%

Formula Markup: C61H107N3O6

Formula Weight: 978,5

Shelf life (days): 1095

Notes: Lipid 331 is a biodegradable cyclic ionizable cationic lipid (pKa = 7.53) that has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.{51597} LNPs containing lipid 331 and encapsulating 5-methoxyuridine-modified mRNA encoding ovalbumin induce IFN regulatory factor (IRF) activation in a reporter assay using THP-1 monocytes. Intranasal administration of LNPs containing lipid 331 and DOTAP (Item Nos. 15110 / 38905) and encapsulating mRNA encoding a fusion of the receptor-binding domain (RBD) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein, also known as surface glycoprotein, with mouse complement C3d as an adjuvant increase serum anti-SARS-CoV-2 spike glycoprotein RBD IgG titers in mice.

• Artikelnummer: CAY39771-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39771-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK