Lipid OA2 (hydrochloride)

Formulation: A solid

Formal Name: di((Z)-octadec-9-en-1-yl) L-lysyl-L-glutamate, dihydrochloride

Purity: ≥95%

Formula Markup: C47H89N3O5 • 2HCl

Formula Weight: 849,1

Shelf life (days): 1460

Notes: Lipid OA2 is an ionizable cationic lipid that has been used in the generation of single-component lipid nanoparticles (LNPs) for the delivery of siRNA.{68613} LNPs containing lipid OA2 and siRNA targeting the gene encoding suppressor of cytokine signaling 1 (Socs1) decrease Socs1 expression by approximately 50% in isolated mouse bone marrow dendritic cells (BMDCs). Vaccination with ovalbumin-induced isolated mouse BMDCs transfected with LNPs composed of lipid OA2 and Socs1-targeting siRNA increases survival and decreases tumor volume in a B16-OVA murine melanoma model.

• Artikelnummer: CAY37987-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37987-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK