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LipidLaunch™ LNP Apparent pKa Assay Kit (TNS Method)
LipidLaunch™ LNP Apparent pKa Assay Kit (TNS Method)
Artikelnummer
CAY702680-96
Verpackungseinheit
96 wells
Hersteller
Cayman Chemical
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Formula Weight: 0
Shelf life (days): 365
Notes: Cayman’s LipidLaunch™ LNP Apparent pKa Assay Kit (TNS Method) provides a robust and easy-to-use platform for testing the apparent/global pKa of formulated LNPs. The assay uses a fluorogenic probe, 6-(p-toluidino)-2-naphthalenesulfonic acid sodium salt (TNS). This probe fluoresces in association with positively charged membranes, which can be easily quantified using a fluorescence plate reader at excitation and emission wavelengths of 320 and 450 nm, respectively. TNS loses fluorescence as it dissociates, so a titration of the pH in the presence of LNPs results in a curve, with the 50% maximal fluorescence point called the apparent pKa of the particle.
Shelf life (days): 365
Notes: Cayman’s LipidLaunch™ LNP Apparent pKa Assay Kit (TNS Method) provides a robust and easy-to-use platform for testing the apparent/global pKa of formulated LNPs. The assay uses a fluorogenic probe, 6-(p-toluidino)-2-naphthalenesulfonic acid sodium salt (TNS). This probe fluoresces in association with positively charged membranes, which can be easily quantified using a fluorescence plate reader at excitation and emission wavelengths of 320 and 450 nm, respectively. TNS loses fluorescence as it dissociates, so a titration of the pH in the presence of LNPs results in a curve, with the 50% maximal fluorescence point called the apparent pKa of the particle.
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Gernot Ensinger, M.Sc.
Laurent Haze
