Formulation: A solution in ethanol
Formal Name: 3,6-bis[4-[bis[(9Z,12Z)-2-hydroxy-9,12-octadecadien-1-yl]amino]butyl]-2,5-piperazinedione
Purity: ≥90% (mixture of isomers)
Formula Markup: C84H152N4O6
Formula Weight: 1314,1
Shelf life (days): 365
CAS Number: 1883431-67-1
Notes: OF-02 is an ionizable cationic amino lipid that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA.{64739} LNPs containing OF-02 localize to the liver after intravenous administration in mice. Intravenous administration of LNPs containing OF-02 and encapsulating human erythropoietin (EPO) mRNA increases serum EPO levels in mice.