YSK05, CAS 1318793-78-0

Formulation: A solution in ethanol

Formal Name: 1-methyl-4,4-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]-piperidine

Purity: ≥90%

Formula Markup: C42H77NO2

Formula Weight: 628,1

Shelf life (days): 365

CAS Number: 1318793-78-0

Notes: YSK05 is an ionizable cationic amino lipid (apparent pKa = ~6.5) that has been used in combination with other lipids in the formation of liposomes and lipid nanoparticles (LNPs).{62758,62759,62760} Administration of cyclic di-GMP (Item No. 17144) in YSK05-containing liposomes increases serum levels of IFN-β, IFN-γ, IL-6, and TNF-α and activates natural killer (NK) cells in mice, as well as decreases lung metastasis in a B16/F10 murine melanoma model of metastasis.{62759} Intravenous administration of factor VII siRNA in YSK05-containing LNPs reduces factor VII activity in isolated mouse plasma.{62760}

• Artikelnummer: CAY35786-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 35786-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe