Calcium Channel Blocker Library

Description: Calcium channel blockers (CCBs), also called calcium antagonists are compounds that slow the movement of calcium (Ca2+) through calcium channels into the cells of the heart and blood vessel walls. Calcium causes the heart and arteries to squeeze more strongly. By blocking calcium, calcium channel blockers allow blood vessels to relax and open. So calcium channel blockers are usually used to lower blood pressure, relieve chest pain (angina) and control an irregular heartbeat.
Calcium channel blockers (CCBs), also called calcium antagonists are compounds that slow the movement of calcium (Ca2+) through calcium channels into the cells of the heart and blood vessel walls. Calcium causes the heart and arteries to squeeze more strongly. By blocking calcium, calcium channel blockers allow blood vessels to relax and open. So calcium channel blockers are usually used to lower blood pressure, relieve chest pain (angina) and control an irregular heartbeat.
MCE supplies a unique collection of 149 calcium channel blockers and antagonists, all of which have the identified inhibitory effect on calcium channel. MCE Calcium Channel Blocker Library is a useful tool for discovery of antihypertensive drugs and cardiovascular disease research.
MCE Calcium Channel Blocker Library can be supplied as pre-dissolved Solutions or Solid. For pre-dissolved solutions in this library, there are 146 compounds supplied in 10 mM solution and 3 compounds supplied in 2 mM solution.
For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, and 2 mM for compounds with solubility between 2 mM and 10 mM.

Advantages:

• A unique collection of 149 calcium channel blockers and antagonists for high throughput screening (HTS) and high content screening (HCS).
• A useful tool for the discovery of antihypertensive drugs and anti-cardiovascular drugs.
• Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.
• Structurally diverse, medicinally active, and cell permeable.
• Detailed compound information with structure, IC50, and brief introduction.
• High purity and quality validated by NMR and LC/MS.
• All compounds are in stock and continuously updated.

Formulation: A collection of 149 calcium channel blockers and antagonists supplied as pre-dissolved Solutions or SolidSolution:146 compounds supplied in 10 mM solution,3 compounds supplied in 2 mM solution.

Layout: 96-well storage tube or 96-well plate: 1st and 12th column are left empty.384-well plate: the first two columns and the last two columns are left empty.Compounds with different concentrations or dissolved in different solvents will be put on separate plates.This way of layout may increase the number of plates because there could be three solvents and three concentrations. If you have other requirements, please let us know.

Container: 96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

• Artikelnummer: MEXHY-L117-2x100
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-L117-2x100
• Green Labware: Nein
• Verpackungseinheit: 2 x 100 μl
• Mengeneinheit: PAK