Cysteine Targeted Covalent Fragment Library

Description: Covalent inhibitors are small molecules that can bind specifically to target proteins through covalent bonds and inhibit their biological functions. Although for a long time, covalent targeting has been playing a subordinate role in drug discovery, with an increasing number of reports on successful clinical applications of such drugs, the potential of these agents is now being acknowledged. Currently, cysteine is the most common covalent amino acid residue in a variety of covalent drugs, and various warheads have been developed that can react with cysteine, providing the key building blocks for covalent drugs to form covalent bonds.
Covalent inhibitors are small molecules that can bind specifically to target proteins through covalent bonds and inhibit their biological functions. Although for a long time, covalent targeting has been playing a subordinate role in drug discovery, with an increasing number of reports on successful clinical applications of such drugs, the potential of these agents is now being acknowledged. Currently, cysteine is the most common covalent amino acid residue in a variety of covalent drugs, and various warheads have been developed that can react with cysteine, providing the key building blocks for covalent drugs to form covalent bonds.
To meet the development needs of covalent inhibitors targeting cysteine, MCE has designed a unique collection of 3164 fragments with different covalent warheads that target cysteine. The MCE Cysteine Targeted Covalent Fragment Library is designed using the following covalent warheads: Acrylamides, Propiolic acid ester, Dimethylamine functionalized acrylamides, Chloroacetamides, Acrylonitrile, 2-Cyanoacrylamide, Aziridine, Haloacetamide, etc. All fragments are pre-filtered with the Rule of Three restrictions which can be used for fragment-based covalent drug development.
MCE Cysteine Targeted Covalent Fragment Library can be supplied as pre-dissolved Solutions or Solid. For pre-dissolved solutions in this library, there are 3147 compounds supplied in 10 mM solution and 1 compounds supplied in 2 mM solution.
For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, and 2 mM for compounds with solubility between 2 mM and 10 mM.

Advantages:

• A unique collection of 3164 fragments with different covalent warheads that target cysteine.
• Contains various covalent warheads targeting cysteine residue.
• Compounds were pre-filtered with the Rule of Three restrictions: MW 100-300 Da, H-donors ≤3, H-acceptors ≤3 and cLogP ≤3.
• A useful tool for development covalent drugs.
• Validated NMR and HPLC to ensure high purity and quality.
• All compounds are in stock and continuously updated.

Formulation: A collection of 3164 fragments with various warheads targeting cysteine residue supplied as pre-dissolved Solutions or Solid.Solution:3147 compounds supplied in 10 mM solution,1 compounds supplied in 2 mM solution.

Layout: 96-well storage tube or 96-well plate: 1st and 12th column are left empty.384-well plate: the first two columns and the last two columns are left empty.Compounds with different concentrations or dissolved in different solvents will be put on separate plates.This way of layout may increase the number of plates because there could be three solvents and three concentrations. If you have other requirements, please let us know.

Container: 96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode.

• Artikelnummer: MEXHY-L154-30
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-L154-30
• Green Labware: Nein
• Verpackungseinheit: 30 μl
• Mengeneinheit: STK