Membrane Transporter/Ion Channel Compound Library

Description: Most of molecules enter or leave cells mainly via membrane transport proteins, which play important roles in several cellular functions, including cell metabolism, ion homeostasis, signal transduction, the recognition process in the immune system, energy transduction, etc. There are three major types of transport proteins, ATP-powered pumps, channel proteins and transporters. Transport proteins such as channels and transporters play important roles in the maintenance of intracellular homeostasis, and mutations in these transport protein genes have been identified in the pathogenesis of a number of hereditary diseases. In the central nervous system, ion channels have been linked to, but not limited to, many diseases such asataxias, paralyses, epilepsies, and deafness. This indicates the roles of ion channels in the initiation and coordination of movement, sensory perception, and encoding and processing of information. Ion channels are a major class of drug targets in drug development.
Most of molecules enter or leave cells mainly via membrane transport proteins, which play important roles in several cellular functions, including cell metabolism, ion homeostasis, signal transduction, the recognition process in the immune system, energy transduction, etc. There are three major types of transport proteins, ATP-powered pumps, channel proteins and transporters. Transport proteins such as channels and transporters play important roles in the maintenance of intracellular homeostasis, and mutations in these transport protein genes have been identified in the pathogenesis of a number of hereditary diseases. In the central nervous system, ion channels have been linked to, but not limited to, many diseases such asataxias, paralyses, epilepsies, and deafness. This indicates the roles of ion channels in the initiation and coordination of movement, sensory perception, and encoding and processing of information. Ion channels are a major class of drug targets in drug development.
MCE designs a unique collection of 1392 smal-molecule modulators that can be used for the research of Ion Channel and Membrane Transporter or high throughput screening (HTS) related drug discovery.
MCE Membrane Transporter/Ion Channel Compound Library can be supplied as pre-dissolved Solutions or Solid. For pre-dissolved solutions in this library, there are 1378 compounds supplied in 10 mM solution and 14 compounds supplied in 2 mM solution.
For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, and 2 mM for compounds with solubility between 2 mM and 10 mM.

Advantages:

• A unique collection of 1392 small molecule modulators used for Ion Channel and Membrane Transporter research.
• The library contains compounds targeting Membrane Transporters including Pgp, CRM1, BCRP, etc., and Ion Channels including CFTR, proton pump, sodium pump, calcium pump, etc.
• A useful tool for the research of drug absorption and distribution.
• Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by FDA.
• Structurally diverse, medicinally active, and cell permeable.
• Rich documentation with structure, IC50, and summary.
• NMR and HPLC validated to ensure high purity.
• All compounds are in stock and continuously updated.

Formulation: A collection of 1392 Membrane Transporter/Ion Channel related compounds supplied as pre-dissolved Solutions or SolidSolution:1378 compounds supplied in 10 mM solution,14 compounds supplied in 2 mM solution.

Layout: 96-well storage tube or 96-well plate: 1st and 12th column are left empty.384-well plate: the first two columns and the last two columns are left empty.Compounds with different concentrations or dissolved in different solvents will be put on separate plates.This way of layout may increase the number of plates because there could be three solvents and three concentrations. If you have other requirements, please let us know.

Container: 96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

• Artikelnummer: MEXHY-L011-30
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-L011-30
• Green Labware: Nein
• Verpackungseinheit: 30 μl
• Mengeneinheit: STK