Mitochondrial Toxicity Compound Library

Description: Mitochondria, as the main place of energy supply in life, is essential to maintain normal life activities. Mitochondrial dysfunction is associated with common diseases, such as cardiovascular diseases, neurodegenerative diseases, diabetes and cancer. The heart, brain and liver rely heavily on mitochondrial function as the main organs for drug metabolism. In addition, mitochondria is also a target of many drugs, some of which induce organotoxicity by inducing mitochondrial toxicity.
Mitochondria, as the main place of energy supply in life, is essential to maintain normal life activities. Mitochondrial dysfunction is associated with common diseases, such as cardiovascular diseases, neurodegenerative diseases, diabetes and cancer. The heart, brain and liver rely heavily on mitochondrial function as the main organs for drug metabolism. In addition, mitochondria is also a target of many drugs, some of which induce organotoxicity by inducing mitochondrial toxicity.
MCE contains 470 mitochondrial toxic compounds, which can be used as tool compounds for drug development, organ toxicity and disease mechanism research.
MCE Mitochondrial Toxicity Compound Library can be supplied as pre-dissolved Solutions or Solid. For pre-dissolved solutions in this library, there are 463 compounds supplied in 10 mM solution and 7 compounds supplied in 2 mM solution.
For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, and 2 mM for compounds with solubility between 2 mM and 10 mM.

Advantages:

• A unique collection of 470 mitochondrial toxicity compounds for high throughput screening (HTS) and high content screening (HCS).
• Including autophagy, apoptosis, cell cycle, DNA damge and DNA/RNA synthesis-regulating agent, etc.
• Including antibiotics, anti-cancer drugs, cardiac medications and anti-inflammatory agent, etc.
• Structurally diverse, bioactive and cell permeable.
• More detailed compound information with structure, IC50 and brief introduction.
• NMR and HPLC validated ensure high purity.
• All compounds are in stock and continuously updated.

Formulation: A collection of 470 mitochondrial toxicity compounds supplied as pre-dissolved Solutions or Solid.Solution:463 compounds supplied in 10 mM solution,7 compounds supplied in 2 mM solution.

Layout: 96-well storage tube or 96-well plate: 1st and 12th column are left empty.384-well plate: the first two columns and the last two columns are left empty.Compounds with different concentrations or dissolved in different solvents will be put on separate plates.This way of layout may increase the number of plates because there could be three solvents and three concentrations. If you have other requirements, please let us know.

Container: 96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode.

• Artikelnummer: MEXHY-L155-250
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-L155-250
• Green Labware: Nein
• Verpackungseinheit: 250 μl
• Mengeneinheit: STK