Pyroptosis Compound Library

Description: Programmed cell death pathways, including apoptosis, pyroptosis and necroptosis, are regulated by unique sets of host proteins that coordinate a variety of biological outcomes. Pyroptosis is a highly inflammatory form of programmed cell death that occurs most frequently upon infection with intracellular pathogens and is likely to form part of the antimicrobial response. This process promotes the rapid clearance of various bacterial, viral, fungal and protozoan infections by removing intracellular replication niches and enhancing the host's defensive responses. Pyroptosis has been widely studied in inflammatory and infection disease models. Recently, there are growing evidences that pyroptosis also plays an important role in the development of cancer, cardiovascular diseases and Metabolic disorder, etc.
Programmed cell death pathways, including apoptosis, pyroptosis and necroptosis, are regulated by unique sets of host proteins that coordinate a variety of biological outcomes. Pyroptosis is a highly inflammatory form of programmed cell death that occurs most frequently upon infection with intracellular pathogens and is likely to form part of the antimicrobial response. This process promotes the rapid clearance of various bacterial, viral, fungal and protozoan infections by removing intracellular replication niches and enhancing the host's defensive responses. Pyroptosis has been widely studied in inflammatory and infection disease models. Recently, there are growing evidences that pyroptosis also plays an important role in the development of cancer, cardiovascular diseases and Metabolic disorder, etc.
MCE designs a unique collection of 1256 pyroptosis-related compounds mainly focusing on the key targets in the pyroptosis signaling pathway and can be used in the research of pyroptosis signal pathway and related diseases.
MCE Pyroptosis Compound Library can be supplied as pre-dissolved Solutions or Solid. For pre-dissolved solutions in this library, there are 1232 compounds supplied in 10 mM solution, 19 compounds supplied in 2 mM solution and 5 compounds supplied in 3 mg/mL solution.
For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.

Advantages:

• A unique collection of 1256 small molecules used for pyroptosis research.
• Targets such as Caspase-1, Caspase-4, Caspase-5, gasdermin D, NLRP3 , etc.
• Bioactivity and safety confirmed by preclinical research and clinical trials, some compounds have been approved by FDA.
• A useful tool to study pyroptosis-involved regulation and diseases such as cancer, cardiovascular diseases and Metabolic disorder, etc.
• Structurally diverse, medicinally active, and cell permeable.
• More detailed compound information with structure, IC50, and other chemical & biological data.
• NMR and HPLC validated to ensure high purity and quality.
• All compounds are in stock and continuously updated.

Formulation: A collection of 1256 pyroptosis compounds supplied as pre-dissolved Solutions or SolidSolution:1232 compounds supplied in 10 mM solution,19 compounds supplied in 2 mM solution,5 compounds supplied in 3 mg/mL solution.

Layout: 96-well storage tube or 96-well plate: 1st and 12th column are left empty.384-well plate: the first two columns and the last two columns are left empty.Compounds with different concentrations or dissolved in different solvents will be put on separate plates.This way of layout may increase the number of plates because there could be three solvents and three concentrations. If you have other requirements, please let us know.

Container: 96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

• Artikelnummer: MEXHY-L059-100
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-L059-100
• Green Labware: Nein
• Verpackungseinheit: 100 μl
• Mengeneinheit: STK