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Chemi-Verse™ BLK Kinase Assay Kit
Chemi-Verse™ BLK Kinase Assay Kit
Artikelnummer
BPS82229
Verpackungseinheit
96 reactions
Hersteller
BPS Bioscience
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Products from BPS Bioscience require a minimum order value above 400€
Applications: Study enzyme kinetics and screen small molecule inhibitors for drug discovery and high throughput screening (HTS) applications.
Background: BLK (B lymphocyte kinase) is a member of the Src non-receptor tyrosine kinase family. It is found primarily in B-cells, where it is involved in cell development and maturation signaling pathways. Overexpression of BLK has been associated with autoimmune disorders and B-cell linked-cancers, such as lymphoma and leukemia. Similarly to other Src kinases, BLK is inhibited by dasatinib, a drug approved under the name SPRYCEL® for the treatment of CML (chronic myeloid leukemia) in adults and children. The development of BLK-specific inhibitors is still an active research area, aiming at finding specific and high affinity inhibitors that can be used in the treatment not only of BLK-related lymphoma and leukemia, but also autoimmune disorders.
Contraindications: The final concentration of DMSO in the assay should not exceed 1%.
Description: The Chemi-Verse™ BLK Kinase Assay Kit is designed to measure BLK (B lymphocyte kinase) kinase activity for screening and profiling applications using ADP-Glo™ as a detection reagent. The assay kit comes in a convenient 96-well format, with enough purified recombinant BLK kinase, kinase substrate, ATP, and kinase assay buffer for 100 enzyme reactions.
Storage Stability: This assay kit will perform optimally for up to 6 months from date of receipt when the materials are stored as directed
Uniprot: P51451
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
References: Yang S., et al., 2023 J Biomol Struct Dyn: 1-11.
Fu T., et al., 2022 Eur J Med Chem 229: 114051.
Applications: Study enzyme kinetics and screen small molecule inhibitors for drug discovery and high throughput screening (HTS) applications.
Background: BLK (B lymphocyte kinase) is a member of the Src non-receptor tyrosine kinase family. It is found primarily in B-cells, where it is involved in cell development and maturation signaling pathways. Overexpression of BLK has been associated with autoimmune disorders and B-cell linked-cancers, such as lymphoma and leukemia. Similarly to other Src kinases, BLK is inhibited by dasatinib, a drug approved under the name SPRYCEL® for the treatment of CML (chronic myeloid leukemia) in adults and children. The development of BLK-specific inhibitors is still an active research area, aiming at finding specific and high affinity inhibitors that can be used in the treatment not only of BLK-related lymphoma and leukemia, but also autoimmune disorders.
Contraindications: The final concentration of DMSO in the assay should not exceed 1%.
Description: The Chemi-Verse™ BLK Kinase Assay Kit is designed to measure BLK (B lymphocyte kinase) kinase activity for screening and profiling applications using ADP-Glo™ as a detection reagent. The assay kit comes in a convenient 96-well format, with enough purified recombinant BLK kinase, kinase substrate, ATP, and kinase assay buffer for 100 enzyme reactions.
Storage Stability: This assay kit will perform optimally for up to 6 months from date of receipt when the materials are stored as directed
Uniprot: P51451
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
References: Yang S., et al., 2023 J Biomol Struct Dyn: 1-11.
Fu T., et al., 2022 Eur J Med Chem 229: 114051.
| Artikelnummer | BPS82229 |
|---|---|
| Hersteller | BPS Bioscience |
| Hersteller Artikelnummer | 82229 |
| Green Labware | Nein |
| Verpackungseinheit | 96 reactions |
| Mengeneinheit | PAK |
| Produktinformation (PDF) | Download |
| MSDS (PDF) |
|
Immer für Sie da
Gernot Ensinger, M.Sc.
Laurent Haze
