LCK Assay Kit

Products from BPS Bioscience require a minimum order value above 400€

Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.

Background: LCK is a tyrosine kinase that phosphorylates the CD3 receptor and is essential for T cell development and activation. LCK also associates with the cytoplasmic domains of the CD4 and CD8 glycoproteins and interacts with the beta-chain of the interleukin-2 receptor. LCK inhibitors are being investigated as a promising therapeutic approach to autoimmune disease and other inflammatory disorders.

Description: The LCK Assay Kit is designed to measure LCK activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.

Storage Stability: Up to 6 months when stored as recommended.

Supplied As: The LCK Assay Kit comes in a convenient 96-well format, with enough purified recombinant LCK, Protein Tyrosine Kinase Substrate (Poly-Glu,Tyr 4:1), ATP, and kinase assay buffer for 96 enzyme reactions.

Biosafety Level: Not applicable (BSL-1)

References: 1. Yu, C.-L., Jove, R., and Burakoff, S.J. 1997. "Constitutive activation of the Janus kinase-STAT pathway in T lymphoma overexpressing the LCK protein tyrosine kinase." J. Immunology 159 (11): 5206-5210.2. Veillette, A., et al. 1989. "Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56LCK." Nature 338(6212): 257-259.

• Artikelnummer: BPS79794
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 79794
• Green Labware: Nein
• Verpackungseinheit: 96 rxns.
• Mengeneinheit: PAK