Anti-CD19/CD22 Bispecific CAR Lentivirus (Clones FMC63/m971 ScFv-CD8-4-1BB-CD3ζ)

Products from BPS Bioscience require a minimum order value above 400€

Applications: Ideal as a positive control for anti-CD19/CD22 Bispecific CAR evaluation in T cellsUse in transduction optimizationUse to generate anti-CD19/CD22 Bispecific CAR-T cells for research use only, not for therapeutic purposes

Description: The anti-CD19/CD22 Bispecific CAR lentiviruses are replication incompetent, HIV-based, VSV-G-pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. These viruses transduce the ScFv (single-chain variable fragments) of anti-CD19 (clone FMC63) and anti-CD22 (clone m971) linked to a 2^nd generation CAR (Chimeric Antigen Receptor) containing CD8 hinge and transmembrane domains, and the 4-1BB and CD3ζ signaling domains.

Formulation: The lentiviruses were produced from HEK293T cells, concentrated, and resuspended in DMEM.

Storage Stability: Lentiviruses are shipped with dry ice. For long term storage, it is recommended to store the virus at -80°C. Avoid repeated freeze-thaw cycles. Titers can drop significantly with each freeze-thaw cycle.

Supplied As: 50 µl of anti-CD19/CD22 Bispecific CAR Lentivirus at a titer ≥ 10⁸ TU/ml. The titer will vary with each lot; the exact value is provided with each shipment.

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: BSL-2

• Artikelnummer: BPS78609
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 78609
• Verpackungseinheit: 50 µl
• Mengeneinheit: STK