Product Description: FPR2 agonist 2 is a potent and permeates the blood?brain barrier FPR2 agonist with an EC50 of 0.13 μM, 1.1 μM for FPR2 and FPR1, respectively. FPR2 agonist 2 inhibits the production of pro-inflammatory cytokines, counterbalances the changes in mitochondrial function, and inhibits caspase-3 activity[1].
Applications: COVID-19-immunoregulation
Formula: C25H20F2N4O2
References: [1]Mastromarino M, et al. Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Ureidopropanamides as Formyl Peptide Receptor 2 (FPR2) Agonists to Target the Resolution of Inflammation in Central Nervous System Disorders. J Med Chem. 2022; 65(6):5004-5028.
CAS Number: 2829263-20-7
Molecular Weight: 446.45
Compound Purity: 99.59
Research Area: Infection; Neurological Disease
Solubility: DMSO : 50 mg/mL (ultrasonic)
Target: Formyl Peptide Receptor (FPR)
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