FSEN1, CAS 862808-01-3

Formulation: A crystalline solid

Formal Name: 3-(4-bromophenyl)-6-[[4-(4-methoxyphenyl)-1-piperazinyl]methyl]-thiazolo[2,3-c]-1,2,4-triazole

Purity: ≥95%

Formula Markup: C22H22BrN5OS

Formula Weight: 484,4

Shelf life (days): 1460

CAS Number: 862808-01-3

Notes: FSEN1 is an inhibitor of ferroptosis suppressor protein 1 (FSP1; IC50 = 313 nM).{67247} It is selective for FSP1 over NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1; IC50 = >100 µM). FSEN1 induces cell death in GPX4-/- H460 non-small cell lung cancer (NSCLC) cells (EC50 = 69.36 nM) but not control H460 cells expressing Cas9 (H460Cas9). It sensitizes A549, Huh7, HCC1143, U2OS, SU-DHL-5, and T98G cancer cells to ferroptosis induced by (1S,3R)-RSL3 (Item No. 19288) when used at concentrations ranging from 10 to 1,000 nM. FSEN1 also sensitizes H460Cas9 cells, but not FSP1-/- H460 cells, to cell death induced by the ferroptosis inhibitors dihydroartemisinin (Item No. 19846) or FINO2 (Item No. 25096).

• Artikelnummer: CAY38025-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38025-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: Reinstoffe