FTY720 Hydrochloride, CAS 162359-56-0

S1P receptor ligand

Product Type: Agonist

CAS No.: 162359-56-0

MolecularFormula: C19H34ClNO2

Molecular Weight: 343,9

Source: Synthetic

Purity: >98% (TLC); NMR (Conforms)

Solubility: Soluble to 100 mg/ml in DMSO or to 40 mg/ml in ethanol (warmed)

Appearance: White solid

PubChem CID: 107969

Scientific Background: FTY720 is a potent sphingosine 1-phosphate receptors (S1P) agonist once it is phosphorylated by sphingosine kinase. This causes lymphocytes to be sequestered in lymph nodes, which also makes FTY720 an immune modulating drug for multiple sclerosis. It has been shown to stimulate neuronal gene expression, axonal growth and regeneration (3). And recently FTY720 has also been shown to reduce α-Synuclein pathology in parkinsonian GM2+/- Mice (4).

References: 1. Wolf A., et al. (2009) J Immunol. 183(6): 3751-60.2. Brinkmann V., et al. (2002) J Biol Chem. 277(24): 21453-7. 3. Anastasiadou S., and Knoll B. (2016) Exp. Neurol. 279: 243-260. 4. Vidal-Martinez G., at al. (2019) Neuroscience. 411: 1-10.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-523-5MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-523-5MG
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK