GABA-A Receptor Alpha 4 Antibody, Clone N398A/34: ATTO 488

Mouse Anti-Rat GABA-A Receptor Alpha4 Monoclonal IgG1

Target: GABA A Receptor

Conjugate: ATTO 488

Product Type: Monoclonal

Clone Number: N398A/34 (Formerly sold as S398A-34)

Immunogen: Fusion protein amino acids 410-450 (Cytoplasmic C-terminus) of rat GABA-A-Receptor Alpha 4

Swiss-Prot: P28471

Purification: Protein G Purified

Storage Buffer: PBS pH7.4, 50% glycerol, 0.1% sodium azide *Storage buffer may change when conjugated

Concentration: 1 mg/ml

Specificity: Detects ~60kDa. Does not cross-react with other GABA-A-Receptor Alpha subunits.

Cellular Localization: Cell Junction,Synapse,Postsynaptic Cell Membrane,Cell Membrane

Scientific Background: The GABA-A receptor is a member of the superfamily of fast acting ligand-gated ion channels. The individual subunits of these receptors have similar sequences and structural features (1). GABA-A receptors are the major fast inhibitory neurotransmitter gated ion channels in the brain (2). GABA-A Receptor Alpha 4 is associated with epilepsy (3), and research suggests that alterations in GABA- A Receptors subtypes may be involved in the resistance to antiepileptic drugs (4).

References: 1. Bracamontes J.R. and Steinbach J.H. (2008) J Bio Chem. 283: 26128-26136.2. Macdonald R.L., Olsen R.W. (1993) Annu Rev Neurosci. 17: 569-602.3. Grabenstatter H.L., et al. (2014) Epilepsia. 55(11): 1826-1833.4. Bethmann K., Fritschy J.M., Brandt C., Loscher W. (2008) Neurbiol Dis. 31(2): 169-187.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSMC-489D-A488
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SMC-489D-A488
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Rat (Rattus)
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Western Blotting, Immunohistochemistry, Immunocytochemistry
• Isotyp: IgG1
• Human Gene ID: 140675
• Wirt: Mouse