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Galectin-1, His tag, recombinant mouse (rmLGALS1-His)
Galectin-1, His tag, recombinant mouse (rmLGALS1-His)
Artikelnummer
BOL97605.1
Verpackungseinheit
1 mg
Hersteller
Biomol
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Kategorie: Proteins
Formulation: solution
Storage: -20°C
Weight: 17000 D
Purity: >95%
Description: Mouse recombinant LGALS1 produced E.coli is a single polypeptide chain containing 159 amino acids (1-135) and having a molecular mass of 17kDa. LGALS1 is fused to a 24 amino acid His-tag at N-terminus. The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Galectin-1 is an autocrine negative growth factor that regulates cell proliferation. Galectin-1 regulates cell apoptosis and cell differentiation. Galectin-1 binds CD45, CD3 and CD4 and inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of lyn kinase. Galectin-1 and its ligands are one of the master regulators of immune responses as T-cell homeostasis and survival, T-cell immune disorders, inflammation and allergies as well as host–pathogen interactions. Galectin-1 expression or overexpression in tumors and/or the tissue surrounding them must be considered as a sign of the malignant tumor progression that is often related to the long-range dissemination of tumoral cells (metastasis), to their dissemination into the surrounding normal tissue, and to tumor immune-escape. Galectin-1 in its oxidized form plays a number of important roles in the regeneration of the central nervous system after injury. The targeted overexpression (or delivery) of Galectin-1 should be considered as a method of choice for the treatment of some kinds of inflammation-related diseases, neurodegenerative pathologies and muscular dystrophies. In contrast, the targeted inhibition of Galectin-1 expression is what should be developed for therapeutic applications against cancer progression. Galectin-1 is thus a promising molecular target for the development of new and original therapeutic tools. There is 88% homology between the human and mouse galectin-1.
Formulation: solution
Storage: -20°C
Weight: 17000 D
Purity: >95%
Description: Mouse recombinant LGALS1 produced E.coli is a single polypeptide chain containing 159 amino acids (1-135) and having a molecular mass of 17kDa. LGALS1 is fused to a 24 amino acid His-tag at N-terminus. The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Galectin-1 is an autocrine negative growth factor that regulates cell proliferation. Galectin-1 regulates cell apoptosis and cell differentiation. Galectin-1 binds CD45, CD3 and CD4 and inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of lyn kinase. Galectin-1 and its ligands are one of the master regulators of immune responses as T-cell homeostasis and survival, T-cell immune disorders, inflammation and allergies as well as host–pathogen interactions. Galectin-1 expression or overexpression in tumors and/or the tissue surrounding them must be considered as a sign of the malignant tumor progression that is often related to the long-range dissemination of tumoral cells (metastasis), to their dissemination into the surrounding normal tissue, and to tumor immune-escape. Galectin-1 in its oxidized form plays a number of important roles in the regeneration of the central nervous system after injury. The targeted overexpression (or delivery) of Galectin-1 should be considered as a method of choice for the treatment of some kinds of inflammation-related diseases, neurodegenerative pathologies and muscular dystrophies. In contrast, the targeted inhibition of Galectin-1 expression is what should be developed for therapeutic applications against cancer progression. Galectin-1 is thus a promising molecular target for the development of new and original therapeutic tools. There is 88% homology between the human and mouse galectin-1.
| Artikelnummer | BOL97605.1 |
|---|---|
| Hersteller | Biomol |
| Hersteller Artikelnummer | 97605.1 |
| Green Labware | Nein |
| Verpackungseinheit | 1 mg |
| Mengeneinheit | STK |
| Reaktivität | Mouse (Murine) |
| Human Gene ID | 16852 |
| Wirt | Escherichia Coli |
| Produktinformation (PDF) | Download |
| MSDS (PDF) |
|
Immer für Sie da
Gernot Ensinger, M.Sc.
Laurent Haze
