Ganciclovir (sodium salt), CAS 107910-75-8

Formulation: A solid

Formal Name: 2-amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one, monosodium salt

Purity: ≥98%

Formula Markup: C9H12N5O4 • Na

Formula Weight: 277,2

Shelf life (days): 1460

CAS Number: 107910-75-8

Notes: Ganciclovir is an active metabolite of the prodrug valganciclovir (Item No. 13875) and an antiviral nucleoside derivative of 2’-deoxyguanosine (Item No. 9002864).{51563,22180} It reduces human, monkey, mouse, and guinea pig CMV replication in plaque reduction assays (EC50s = 1.3-70 µM).{22180} Topical application of ganciclovir (0.15%) decreases disease severity and corneal leukocyte infiltration in a cat model of ocular feline herpesvirus-1 (FHV-1) epithelial infection.{51566} Ganciclovir (15 mg/kg) prevents allograft histologic injury and natural killer (NK) and myeloid cell infiltration in a mouse model of murine CMV infection with renal transplantation.{51565} It induces tumor regression in a K-BALB murine sarcoma model using a mixed population of cells, which are positive or negative for expression of the gene encoding herpes simplex virus (HSV) thymidine kinase (TK).{51564} Formulations containing ganciclovir have been used in the treatment and prevention of CMV infections.

• Artikelnummer: CAY37487-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37487-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK