Gartanin, CAS 33390-42-0

Formulation: A solid

Formal Name: 1,3,5,8-tetrahydroxy-2,4-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one

Purity: ≥98%

Formula Markup: C23H24O6

Formula Weight: 396,4

Shelf life (days): 1460

CAS Number: 33390-42-0

Notes: Gartanin is a prenylated xanthone that has been found in G. mangostana and has anticancer activity.{68176,68177} It inhibits the growth of T24, UM-UC-3, HT-1376, and TCCSUP bladder cancer cells (IC50s = 4.1-18.1 µM).{68176} Gartanin (10 and 50 µM) increases the number of LC3 puncta, a marker of autophagy, in T24 cells expressing pEGFP-LC3, as well as induces apoptosis in T24 and RT4 cells. It binds to NEDD8-activating enzyme (NAE) and inhibits NEDDylation of cullin 1 and ubiquitin-conjugating enzyme 12 (UBC12) in PC3 and 22Rv1 prostate cancer cells.{68177}

• Artikelnummer: CAY35631-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 35631-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe