Genistein, CAS 446-72-0

Tyrosine kinase inhibitor

Product Type: Inhibitor

CAS No.: 446-72-0

MolecularFormula: C15H10O5

Molecular Weight: 270,2

Source: Synthetic

Purity: ≥98% (HPLC)

Solubility: Soluble in DMSO (30 mg/ml), 100% ethanol (4 mg/ml) or dilute aqueous base; insoluble in water

Appearance: Creamy off-white solid

PubChem CID: 5280961

Scientific Background: Genistein has a wide range of biological actions. It is an inhibitor of tyrosine protein kinase, including epidermal growth factor receptor kinase. It also inhibits DNA topoisomerase and α-glucosidase. It produces cell cycle arrest and apoptosis, and inhibits endocytosis, as well as, inhibits insulin-induced glucose uptake in adipocytes.

References: 1. Akiyama T., et al. (1987) J Biol. Chem. 262(12): 5592–5595.2. Bazuine M., van den Broek P.J.A., & Maassen J. A. (2005) Biochem. Biophys. Res. Comm. 326(2): 511–514. 3. Linassier C., Pierre M., Le Pecq J.B., & Pierre J. (1990) Biochem. Pharm. 39(1): 187–193.4. Dean N.M., Kanemitsu M., & Boynton A.L. (1989) Biochem. Biophys. Res. Comm. 165(2): 795–801.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-446-50MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-446-50MG
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK