GITR / Tnfrsf18 (Mouse)(DTA-1), 1mg/mL

Description: GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25 CD4 Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-B activation, and abrogate the inhibitory function ofCD25 CD4 Tregs. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.

Conjugate: Purified, BSA-free

Concentration: 1 mg/mL

Storage buffer: PBS, no BSA, no azide

Product Origin: Animal - Mus musculus (mouse)

Clone: DTA-1

Entrez Gene ID: 21936

Immunogen: Mouse CD25 CD4 T cells

Expected AB Applications: Flow, surface (published for clone)/Functional studies (published for clone)

Z-Antibody Applications: Flow, surface (published)/Functional studies (published)

• Artikelnummer: BTMBNUM0976-50
• Hersteller: Biotium
• Hersteller Artikelnummer: BNUM0976-50
• Green Labware: Nein
• Verpackungseinheit: 50 uL
• Mengeneinheit: STK
• Reaktivität: Mouse (Murine)
• Klonalität: Monoclonal
• Methode: Flow Cytometry, Functional Studies
• Isotyp: IgG2b kappa
• Wirt: Rat