GL67, CAS 179075-30-0

Formulation: A crystalline solid

Formal Name: 3β-[(3-aminopropyl)[4-[(3-aminopropyl)amino]butyl]carbamate] cholest-5-en-3-ol

Purity: ≥95%

Formula Markup: C38H70N4O2

Formula Weight: 615

Shelf life (days): 730

CAS Number: 179075-30-0

Notes: GL67 is a multivalent ionizable cationic lipid composed of spermine (Item No. 18041) conjugated to cholesterol (Item No. 9003100).{68322} It has been used in the generation of liposomes complexed with plasmid DNA for use in vitro and in vivo. GL67 has also been used in combination with DC-Chol (Item No. 16943) and 1,2-dioloeyl-sn-glycero-3-PE (1,2-DOPE; Item No. 15091) in the generation of lipid nanocarriers for the delivery of siRNA to A549 lung cancer cells.{51364} GL67-containing liposomes, in complex with plasmid DNA for the gene encoding cystic fibrosis transmembrane conductance regulator (CFTR), leads to the expression of functional wild-type CFTR in HEK293 cells.{68323} Aerosol administration of GL67-containing liposomes, in complex with plasmid DNA for the gene encoding CFTR, increases trachea and whole lung mRNA levels of CFTR.

• Artikelnummer: CAY34371-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 34371-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe