GPC3 - CHO-K1 Recombinant Cell Line

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Applications: 1. Useful for screening and validating antibodies against GPC3 and anti-GPC3 CAR-T for immunotherapy research and drug discovery.
2. Useful for GPC3 binding assays to screen for GPC3 ligands.

Background: GPC3, also known as Glypican-3 and OCI5, belongs to the glypican family and is highly expressed in the lungs, liver and kidneys. Its function is tissue dependent and can either promote or suppress tumorigenesis. Being a heparin sulfate proteoglycan, it is overexpressed in neoplasms including malignant melanoma, hepatocellular carcinoma, and testicular yolk sac tumors and plays a significant role in cell growth and differentiation.

Description: Recombinant CHO-K1 cells expressing GPC3 (Glypican 3), a cell surface proteoglycan bearing heparin-sulfate; ref. seq. NM_004484.2.

Host Cell Line: CHO-K1

Mycoplasma Testing: The cell line has been screened using the MycoAlert™ Mycoplasma Detection kit (Lonza, #LT07-218) to confirm the absence of Mycoplasma species.

Storage Stability: Cells will arrive upon dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.

Supplied As: Each vial contains ~ 2 x 10^6 cells in 1 ml of 10% DMSO in FBS.

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: BSL-1

• Artikelnummer: BPS78100
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 78100
• Verpackungseinheit: 2 vials
• Mengeneinheit: PAK
• Wirt: Hamster