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GRID2 Polyclonal Antibody, Rabbit
GRID2 Polyclonal Antibody, Rabbit
Artikelnummer
ELSE-AB-92148-60
Verpackungseinheit
60 µl
Hersteller
Elabscience Biotechnology
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Abbreviation: GRID2
Target Synonym: GluD2;SCAR18;GRID2
Conjugation: Unconjugated
UNIProt ID: O43424
Background: The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans. [provided by RefSeq, Apr 2014]
Concentration: 1mg/mL
Immunogen: A synthetic peptide of human GRID2
Dilution: WB 1:500-1:2000,IF 1:50-1:200
Target Synonym: GluD2;SCAR18;GRID2
Conjugation: Unconjugated
UNIProt ID: O43424
Background: The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans. [provided by RefSeq, Apr 2014]
Concentration: 1mg/mL
Immunogen: A synthetic peptide of human GRID2
Dilution: WB 1:500-1:2000,IF 1:50-1:200
| Artikelnummer | ELSE-AB-92148-60 |
|---|---|
| Hersteller | Elabscience Biotechnology |
| Hersteller Artikelnummer | ELA-E-AB-92148-60 |
| Green Labware | Nein |
| Verpackungseinheit | 60 µl |
| Mengeneinheit | STK |
| Reaktivität | Human, Mouse (Murine), Rat (Rattus) |
| Klonalität | Polyclonal |
| Methode | Immunofluorescence, Western Blotting |
| Isotyp | IgG |
| Wirt | Rabbit |
| Produktinformation (PDF) | Download |
| MSDS (PDF) | Download |
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Gernot Ensinger, M.Sc.
Laurent Haze
