GSK1482160, CAS 1001389-72-5

Formulation: A solid

Formal Name: (2S)-N-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-1-methyl-5-oxo-2-pyrrolidinecarboxamide

Purity: ≥95%

Formula Markup: C14H14ClF3N2O2

Formula Weight: 334,7

Shelf life (days): 1460

CAS Number: 1001389-72-5

Notes: GSK1482160 is an antagonist of the purinergic P2X7 receptor (IC50 = 3.2 nM for the human receptor).{67933} It inhibits increases in the levels of reactive oxygen species (ROS) induced by LPS and BzATP (Item No. 15577) in THP-1 macrophages when used at a concentration of 1 µM.{67934} GSK1482160 (20 mg/kg twice per day) decreases the accumulation of misfolded tau aggregates in the brain and improves learning and memory in the Y-maze and contextual fear conditioning tests in human P301S tau transgenic mice.{67935} It reverses mechanical allodynia in a rat model of chronic constriction injury-induced allodynia when administered at a dose of 20 mg/kg.{67933}

• Artikelnummer: CAY41980-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 41980-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK