GYKI 53655, CAS 143692-48-2

Formulation: A solid

Formal Name: 5-(4-aminophenyl)-8,9-dihydro-N,8-dimethyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide, monohydrochloride

Purity: ≥95%

Formula Markup: C19H20N4O3 • HCl

Formula Weight: 388,9

Shelf life (days): 1460

CAS Number: 143692-48-2

Notes: GYKI 53655 is an allosteric AMPA receptor antagonist.{51508} It inhibits AMPA- and kainite-induced inward currents in whole-cell patch-clamp assays using primary rat hippocampal neurons (IC50s = 1.1 and 1.5 µM, respectively). GYKI 53655 decreases tonic and clonic audiogenic seizure severity in mice (ED50s = 1.3 and 2 mg/kg, respectively) and reduces mortality in a mouse model of global cerebral ischemia induced by magnesium dichloride (ED50 = 8.2 mg/kg).{51509} It inhibits seizures induced by maximal electroshock (MES) in mice (ED50 = 4.6 mg/kg) but induces motor impairment at a half-maximal toxic dose (TD50) value of 8.7 mg/kg.{51508}

• Artikelnummer: CAY39842-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39842-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK