Harmine, CAS 442-51-3

Formulation: A crystalline solid

Formal Name: 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole

Purity: ≥98%

Formula Markup: C13H12N2O

Formula Weight: 212,3

Shelf life (days): 1460

CAS Number: 442-51-3

Notes: Peroxisome proliferator-activated receptor γ (PPARγ) is a central regulator of adipocyte differentiation and is the principle target of the thiazolidinedione (TZD) class of antidiabetic drugs.{10162} Harmine is a β-carboline alkaloid that was first isolated from seeds of Peganum harmala (Syrian rue) and Banisteriopsis caapi. Recent work indicates that harmine is a unique regulator of PPARγ expression that acts by inhibiting the Wnt signalling pathway in a cell-specific manner.{14921} Administration of harmine (30 mg/kg) to obese db/db mice resulted in reduced blood glucose, free fatty acids, and triglyceride levels, delayed hyperglycemia, and improved insulin sensitivity. Harmine also attenuates inflammatory gene expression (TNF-α, IL-1β, iNOS) and macrophage accumulation in adipose tissue.{14921}

• Artikelnummer: CAY10010324-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 10010324-500
• Green Labware: Nein
• Verpackungseinheit: 500 mg
• Mengeneinheit: STK
• Methode: Reinstoffe