Histone H2A.XS139ph (phospho Ser139) antibody

Application Note: WB: 1:500-1:3000. IHC-P: 1:100-1:2000. IHC-Wm: 1:100-1:500. IHC: 1:100-1:2000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Calculated MW: 15

Form: Liquid

Buffer (with preservative): PBS, 1% BSA, 20% Glycerol, 0.025% ProClin 300.

Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)

Background: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

Uniprot ID: Q7ZUY3

Antigen Species: Zebrafish

Immunogen: Carrier-protein conjugated synthetic peptide surrounding phospho Ser139 of zebrafish Histone H2A.X. The exact sequence is proprietary.

Purification: Purified by antigen-affinity chromatography.

Conjugation: Unconjugated

Full Name: H2A histone family, member X

• Artikelnummer: GTX127342-S-25
• Hersteller: GeneTex
• Hersteller Artikelnummer: GTX127342-S-25
• Green Labware: Nein
• Verpackungseinheit: 25 μl
• Mengeneinheit: STK
• Reaktivität: Human, Zebrafish
• Klonalität: Polyclonal
• Methode: Immunofluorescence, Immunohistochemistry (frozen), Immunohistochemistry (paraffin), Western Blotting, Immunohistochemistry, Immunocytochemistry
• Isotyp: IgG
• Human Gene ID: 394048
• Wirt: Rabbit