Products from BPS Bioscience require a minimum order value above 400€Encompassing Amino Acids: 2-126(end)
Applications: Useful as a substrate for histone methyltransferase and acetyltransferase assays. Ideal for screening small molecular inhibitors of histone modifying enzymes for drug discovery and HTS applications.
Description: Human Histone 2B, GenBank Accession No. NM_003528, a.a. 2-126(end) with N-terminal His-tag, MW = 14.6 kDa, expressed in an E. coli expression system.
Format: Aqueous buffer solution
Formulation: 50 mM Tris-HCl, pH 8.0, 150 mM NaCl, 10% glycerol, 1 mM PMSF and 1 mM DTT.
Genbank: NM_003528
Host Cell Line: E. coli
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal His-tag
Uniprot: Q16778
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Osley, M.A., Brief Funct. Genomic Proteomic. 5(3):179-89 (2006).
2. Wyrick, J.J. and Parra, M.A., Biochim Biophys Acta. 1789(1):37-44 (2009).
3. Emre, N.C. and Berger, S.L., Cold Spring Harb Symp Quant Biol. 69: 289-99 (2004).Application Reference(s):
Differential mode of antimicrobial actions of arginine-rich and lysine-rich histones against Gram-positive Staphylococcus aureus (2013)