Histone H3 (K27M), His-tag Recombinant

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Encompassing Amino Acids: 2-136(end) with K27M mutation

Applications: Useful as a substrate for methyltransferases or acetyltransferases and for screening inhibitors and selectivity profiling for drug discovery.

Description: Human Histone 3(HIST1H3E), GenBank Accession No.NM_003532, a.a. 2-136(end) with K27Mmutation and N-terminal His-tag, MW =16.2 kDa, expressed in an E. coliexpression system.

Format: Aqueous buffer solution

Formulation: 8 mM PBS pH 7.4, 110 mM NaCl, 2.2 mM KCl and 20% glycerol

Genbank: NM_003532

Host Cell Line: E. coli

Storage Stability: At least 6 months at -80°C.

Tags: N-terminal His-tag

Uniprot: P68431

Warnings: Avoidfreeze/thaw cycles. Storing diluted proteinis not recommended, if necessary, usecarrier protein (BSA 0.1 - 0.5%).

Biosafety Level: Not applicable (BSL-1)

References: 1. Loyola, A., et al., Mol. Cell. 2006; 24(2): 309-316.
2. Khuong-Quang, D-A., et al., Acta. Neuropathol. 2012; 10.1007/s00401-012-0998-0.Application Reference(s):
Differential mode of antimicrobial actions of arginine-rich and lysine-rich histones against Gram-positive Staphylococcus aureus (2013)

• Artikelnummer: BPS52101
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 52101
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK