Histone H3K9Me2 Polyclonal Antibody

Formulation: 500 µl of peptide affinity-purified polyclonal antibody

Immunogen: Synthetic peptide from human H3K9Me2 (aa 1-30) conjugated to KLH

Shelf life (days): 1095

Notes: Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.{57056} It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination.{57056,53978} Dimethylation of histone H3 at lysine 9 (H3K9Me2) is associated with transcriptional repression.{48220} Heterochromatin protein 1-α (HP1-α), HP1-β, and HP1-γ selectively bind histone H3 N-terminal peptides containing dimethylated lysine 9 over unmodified lysine 9.{20846} High nuclear levels of H3K9Me2 in tumor tissue are associated with decreased disease-specific and disease-free survival in patients with oral and oropharyngeal squamous cell carcinoma.{49115} Cayman’s Histone H3K9Me2 Polyclonal Antibody can be used for ELISA.

• Artikelnummer: CAY18199-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 18199-500
• Green Labware: Nein
• Verpackungseinheit: 1 ea (500 µl)
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Polyclonal
• Methode: ELISA
• Wirt: Rabbit