Product Description: HOIPIN-8 is a potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) with an IC50 of 11 nM. HOIPIN-8 is a HOIPIN-1 derivative with enhanced the potency by 255-fold in the petit-LUBAC inhibition, and 10-fold and 4-fold in the LUBAC- and TNF-α-mediated NF-κB activation, respectively than HOIPIN-1. HOIPIN-1 is a promising tool to explore the cellular functions of LUBAC[1].
Applications: COVID-19-immunoregulation
Formula: C23H15F2N4NaO3
References: [1]Ken Katsuya, et al. Small-molecule Inhibitors of Linear Ubiquitin Chain Assembly Complex (LUBAC), HOIPINs, Suppress NF-κB Signaling. Biochem Biophys Res Commun. 2019 Feb 12;509(3):700-706.
CAS Number: 2519537-70-1
Molecular Weight: 456.38
Compound Purity: 99.89
Research Area: Inflammation/Immunology
Solubility: DMSO : 50 mg/mL (ultrasonic)
Target: E1/E2/E3 Enzyme
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