HPK1 Assay Kit

Products from BPS Bioscience require a minimum order value above 400€

Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.

Background: HPK1 (MAP4K1) or Hematopoietic progenitor kinase 1 is a hematopoietic cell-restricted member of the Ste20 serine/threonine kinase super family. It is a tissue-specific upstream activator of the MEKK/JNK/SAPK signaling pathway. HPK1 diminishes T cell receptor (TCR) signaling activity and T cell proliferation by phosphorylating the adaptor protein SLP-76, suggesting HPK1 could be a novel target for anti-tumor immunotherapy.

Description: The HPK1 Assay Kit is designed to measure HPK1 activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.

Storage Stability: Up to 6 months when stored as recommended

Supplied As: The HPK1 Assay Kit comes in a convenient 96-well format, with enough purified recombinant HPK1 enzyme, HPK1 substrate, ATP, and kinase assay buffer for 100 enzyme reactions.

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: Not applicable (BSL-1)

References: 1. Wu P, et al., Structure, 2019, 27: 125-133.e4
2. Alzabin S, et al., J. Immunol. 2009, 182: 6187-6194
3. Jakob SM, et al., Blood, 2013, 121(20):4184-4194

• Artikelnummer: BPS79775
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 79775
• Green Labware: Nein
• Verpackungseinheit: 96 rxns.
• Mengeneinheit: PAK