HSP47 Antibody, Clone 1C4-1A6: HRP

Mouse Anti-Human HSP47 Monoclonal IgG1 Kappa

Target: HSP47

Conjugate: HRP

Product Type: Monoclonal

Clone Number: 1C4-1A6

Immunogen: Human HSP47, full length

Swiss-Prot: P50454.2

Purification: Protein G Purified

Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

Concentration: 1 mg/ml

Specificity: Detects 47kDa.

Cellular Localization: Endoplasmic Reticulum,Endoplasmic Reticulum Lumen

Scientific Background: HSP47 is a chaperone protein, member of the superfamily of serine proteinase inhibitors. Also known as SERPINH1, a serine proteinase inhibitor. It is a stress protein that resides in the endoplasmic reticulum, has an active role on the intracellular process of folding, assembly and secretion of pro-collagens. Recent studies have shown the association of on an increased expression of HSP47 around fibrotic lesions (1).The identification of a novel biomarker on cell therapies aimed to reduce the progression of fibrotic diseases, could be used potentially as a universal marker, since HSP47 binds a single substrate (2). Type I collagen is fundamental during the healing process after a myocardial infarction. It is critical in the position of collagen-produced cells and the assembly of collagen fibrils (3).

References: 1. Razzaque MS., Taquchi T., (1999) Histol Histopathol. 14 (4): 1999-212.2. Taguchi T., et al. (2011) Acta Histochem Cytochem. 44(2):35-41. 3. Nong Z., et al. (2011) Am J Pathol. 197(5): 2189-96.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSMC-203B-HRP
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SMC-203B-HRP
• Green Labware: Nein
• Verpackungseinheit: 200 µg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Western Blotting, Immunocytochemistry
• Isotyp: IgG1 kappa
• Human Gene ID: 871
• Wirt: Mouse