Human GM-CSF protein (active)

Species: Human

Product Description: GM-CSF, a colony stimulating factor also known as CSF2, mediates the proliferation, differentiation, and functions of hematopoietic precursor cells. This bioactive recombinant human GM-CSF is a 14.6 kDa globular protein formed by a 128 a.a. polypeptide with two intramolecular disulfide bonds and two potential N-linked glycosylation sites.

Application Note: The ED₅₀ was determined by a cell proliferation assay using TF-1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 10⁷ units/mg.

Form: Lyophilized powder

Buffer (with preservative): Reconstitute with distilled water to 0.1 mg/ml. Lyophilized from 50mM PBS, 100mM NaCl, 5% Trehalose, no Preservative.

Concentration: (Please refer to the vial label for the specific concentration.)

Background: The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008]

Uniprot ID: P04141

Region Sequence: Human full-length GM-CSF protein (18-144 a.a. of NP_000749.2, signal peptide removed)

ExpressionSystem: E. Coli

Conjugation: Unconjugated

Full Name: colony stimulating factor 2

• Artikelnummer: GTX137974-PRO-100
• Hersteller: GeneTex
• Hersteller Artikelnummer: GTX137974-PRO-100
• Verpackungseinheit: 100 μg
• Mengeneinheit: STK
• Methode: Functional Assay
• Human Gene ID: 1437