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CDC37 Protein
Human Recombinant CDC37 Protein
Artikelnummer
STRSPR-304B
Verpackungseinheit
100 µg
Hersteller
Stressmarq Biosciences
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Target: CDC37 .
Nature: Recombinant.
Swiss-Prot: Q16543.
Expression System: E. coli.
Amino Acid Sequence: MGHHHHHHMVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAEGGKAELERLQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLSKDGFSKSMVNTKPEKTEEDSEEVREQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTKIKTADRQYMEGFNDELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKASEAKEGEEAGPGDPLLEAVPKTGDEKDVSV.
Purification: Affinity Purified.
Purity: >90%.
Storage Buffer: 25mM Tris buffer pH7.2, 150mM NaCl, 0.1 mM DTT, 50% glycerol.
Protein Size: ~44.5 kDa.
Conjugate: His tag.
Cellular Localization: Cytoplasm.
Scientific Background: HSP90 co-chaperone Cdc37 is a protein that is encoded by the CDC37 gene. It has been found to form complexes with HSP90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF1, MOK and elF-2 alpha kinases. It is thought to play a critical role in directing HSP90 to its target kinases (1, 2). CDC37 is necessary for maintaining prostate tumor cell growth and represents a novel target in the exploration for multi-targeted therapies (3, 4).
References: 1. Dai K., Kobayashi R., Beach D. (1996) J Biol Chem. 271(36): 22030-22034.2. Stepanova L., Leng X., Parker S.B., Harper J.W. (1996) Genes Dev. 10(12): 1491-1502.3. Kimura Y., et al. (1997) Genes Dev. 11(14): 1775-1185.4. Gray P.J., et al. (2008) Nat Rev Cancer. 8(7): 491-495.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
Nature: Recombinant.
Swiss-Prot: Q16543.
Expression System: E. coli.
Amino Acid Sequence: MGHHHHHHMVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAEGGKAELERLQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLSKDGFSKSMVNTKPEKTEEDSEEVREQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTKIKTADRQYMEGFNDELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKASEAKEGEEAGPGDPLLEAVPKTGDEKDVSV.
Purification: Affinity Purified.
Purity: >90%.
Storage Buffer: 25mM Tris buffer pH7.2, 150mM NaCl, 0.1 mM DTT, 50% glycerol.
Protein Size: ~44.5 kDa.
Conjugate: His tag.
Cellular Localization: Cytoplasm.
Scientific Background: HSP90 co-chaperone Cdc37 is a protein that is encoded by the CDC37 gene. It has been found to form complexes with HSP90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF1, MOK and elF-2 alpha kinases. It is thought to play a critical role in directing HSP90 to its target kinases (1, 2). CDC37 is necessary for maintaining prostate tumor cell growth and represents a novel target in the exploration for multi-targeted therapies (3, 4).
References: 1. Dai K., Kobayashi R., Beach D. (1996) J Biol Chem. 271(36): 22030-22034.2. Stepanova L., Leng X., Parker S.B., Harper J.W. (1996) Genes Dev. 10(12): 1491-1502.3. Kimura Y., et al. (1997) Genes Dev. 11(14): 1775-1185.4. Gray P.J., et al. (2008) Nat Rev Cancer. 8(7): 491-495.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
| Artikelnummer | STRSPR-304B |
|---|---|
| Hersteller | Stressmarq Biosciences |
| Hersteller Artikelnummer | SPR-304B |
| Green Labware | Nein |
| Verpackungseinheit | 100 µg |
| Mengeneinheit | STK |
| Reaktivität | Human |
| Methode | Western Blotting, Functional Assay, SDS-PAGE |
| Human Gene ID | 11140 |
| Produktinformation (PDF) | Download |
| MSDS (PDF) | Download |
Immer für Sie da
Gernot Ensinger, M.Sc.
Laurent Haze
