Product Description: Hyodeoxycholic acid is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC50 of 31.6 µM in CHO cells.
Applications: Metabolism-sugar/lipid metabolism
Formula: C24H40O4
References: [1]Sato H, et al. Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. J Med Chem. 2008 Mar 27;51(6):1831-41./[2]Shih DM, et al. Hyodeoxycholic acid improves HDL function and inhibits atherosclerotic lesion formation in LDLR-knockout mice. FASEB J. 2013 Sep;27(9):3805-17.
CAS Number: 83-49-8
Molecular Weight: 392.57
Compound Purity: 99.87
Research Area: Metabolic Disease
Solubility: DMSO : 100 mg/mL (ultrasonic)/H2O : < 0.1 mg/mL
Target: Endogenous Metabolite;G protein-coupled Bile Acid Receptor 1
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