Product Description: IC87201, an inhibitor of PSD95-nNOS protein-protein interactions, suppresses NMDAR-dependent NO and cGMP formation.
Applications: Neuroscience-Neurodegeneration
Formula: C13H10Cl2N4O
References: [1]Bach A, et al. Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions. Sci Rep. 2015 Jul 16;5:12157./[2]Smith AE, et al. Source memory in rats is impaired by an NMDA receptor antagonist but not by PSD95-nNOS protein-protein interaction inhibitors. Behav Brain Res. 2016 May 15;305:23-9./[3]Doucet MV, et al. Small-molecule inhibitors at the PSD-95/nNOS interface protect against glutamate-induced neuronal atrophy in primary cortical neurons. Neuroscience. 2015 Aug 20;301:421-38.
CAS Number: 866927-10-8
Molecular Weight: 309.15
Compound Purity: 97.24
Research Area: Neurological Disease
Solubility: DMSO : ≥ 100 mg/mL
Target: iGluR
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