Product Description: IDO1/TDO-IN-4 is a potent IDO1/TDO dual inhibitor, with IC50 values of 3.53 μM (IDO1) and 1.15 μM (TDO). IDO1/TDO-IN-4 forms hydrogen bond with IDO1, and π?π stacking interaction with TDO. IDO1/TDO-IN-4 can be used in the research of depression, and depression-induced infectious, metabolic, and autoimmune disorders[1].
Applications: COVID-19-immunoregulation
Formula: C14H10N4
References: [1]Yu Zhang, et al. B Discovery of 1-(Hetero)aryl-β-carboline Derivatives as IDO1/TDO Dual Inhibitors with Antidepressant Activity. J Med Chem. 2022 Aug 7.
CAS Number: 461424-21-5
Molecular Weight: 234.26
Compound Purity: 99.23
Research Area: Inflammation/Immunology; Neurological Disease
Solubility: DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C)/Methanol : 16.67 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Indoleamine 2,3-Dioxygenase (IDO)
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