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Ikaros antibody (JB50-38)
Ikaros antibody (JB50-38)
Artikelnummer
GTX01051-100
Verpackungseinheit
100 μl
Hersteller
GeneTex
Verfügbarkeit:
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Clone Name: JB50-38
Application Note: WB: 1:500-1:2000. IHC-P: 1:50-1:200. FACS: 1:50-1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 58
Form: Liquid
Buffer (with preservative): 1x TBS (pH7.4), 1% BSA, 40% Glycerol, 0.05% Sodium azide.
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]
Uniprot ID: Q13422
Antigen Species: Human
Immunogen: Recombinant protein
Purification: Protein A purified
Conjugation: Unconjugated
Full Name: IKAROS family zinc finger 1
Application Note: WB: 1:500-1:2000. IHC-P: 1:50-1:200. FACS: 1:50-1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 58
Form: Liquid
Buffer (with preservative): 1x TBS (pH7.4), 1% BSA, 40% Glycerol, 0.05% Sodium azide.
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]
Uniprot ID: Q13422
Antigen Species: Human
Immunogen: Recombinant protein
Purification: Protein A purified
Conjugation: Unconjugated
Full Name: IKAROS family zinc finger 1
| Artikelnummer | GTX01051-100 |
|---|---|
| Hersteller | GeneTex |
| Hersteller Artikelnummer | GTX01051-100 |
| Green Labware | Nein |
| Verpackungseinheit | 100 μl |
| Mengeneinheit | STK |
| Reaktivität | Human, Mouse (Murine) |
| Klonalität | Recombinant |
| Methode | Immunohistochemistry (paraffin), Western Blotting, Flow Cytometry |
| Isotyp | IgG |
| Human Gene ID | 10320 |
| Wirt | Rabbit |
| Produktinformation (PDF) | Download |
| MSDS (PDF) | Download |
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