IL-12, Human (HEK293, His)

Product Description: Interleukin-12 subunit alpha (IL-12A; IL-12p35), an immune-suppressive cytokine, encodes a subunit of the cytokine IL-12 that acts on T and natural killer cells, and has a broad array of biological activities. IL-12A heterodimerizes with IL-12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine[1][2]. IL-12 Protein, Human (547a.a, HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag . It consists of IL-12A (M1-S219) and IL-12B (M1-S328).

Formula: 3592&3593(Gene_ID)P29459 (R23-S219) & P29460 (I23-S328)(Accession)

References: [1]D De Wit, et al. Helper T-cell responses elicited by Der p 1-pulsed dendritic cells and recombinant IL-12 in atopic and healthy subjects. J Allergy Clin Immunol. 2000 Feb;105(2 Pt 1):346-52./[2]Jin Kyeong Choi, et al. IL-12p35 Inhibits Neuroinflammation and Ameliorates Autoimmune Encephalomyelitis. Front Immunol. 2017 Oct 5;8:1258./[3]Ivy M Dambuza, et al. IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease. Nat Commun. 2017 Sep 28;8(1):719.

Molecular Weight: Approximately 40&43 kDa

Compound Purity: 96.00

• Artikelnummer: MEXHY-P73898-100UG
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P73898-100UG
• Green Labware: Nein
• Verpackungseinheit: 100 μg
• Mengeneinheit: STK