IL-17A, Mouse (CHO)

Product Description: IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases[1][2]. IL-17A Protein, Mouse (CHO) is a recombinant mouse IL-17A protein and is expressed in CHO cells. It consists of 133 amino acids (A26-A158).

Formula: 16171(Gene_ID)Q62386 (A26-A158)(Accession)

References: [1]Iwakura Y, et al. The roles of IL-17A in inflammatory immune responses and host defense against pathogens. Immunol Rev. 2008 Dec;226:57-79./[2]Chen K, et al. Interluekin-17A (IL17A). Gene. 2017 May 30;614:8-14./[3]Wright JF, et al. The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex. J Immunol. 2008 Aug 15;181(4):2799-805./[4]Cua DJ, et al. Innate IL-17-producing cells: the sentinels of the immune system. Nat Rev Immunol. 2010 Jul;10(7):479-89./[5]Pelidou SH, et al. Enhancement of acute phase and inhibition of chronic phase of experimental autoimmune neuritis in Lewis rats by intranasal administration of recombinant mouse interleukin 17: potential immunoregulatory role. Exp Neurol. 2000 May;163(1):165-72./[6]Liu Y, et al. IL-17A and TNF-α exert synergistic effects on expression of CXCL5 by alveolar type II cells in vivo and in vitro. J Immunol. 2011 Mar 1;186(5):3197-205.

Molecular Weight: Approximately 15-22 kDa due to the glycosylation.

Compound Purity: 95.00

• Artikelnummer: MEXHY-P7372-2UG
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P7372-2UG
• Green Labware: Nein
• Verpackungseinheit: 2 μg
• Mengeneinheit: STK