IMR-1A, CAS 331862-41-0

Formulation: A crystalline solid

Formal Name: 2-[2-methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl],phenoxy]-acetic acid

Purity: ≥95%

Formula Markup: C13H11NO5S2

Formula Weight: 325,4

Shelf life (days): 1460

CAS Number: 331862-41-0

Notes: IMR-1A is an inhibitor of Notch ternary complex formation (IC50 = 0.5 µM) and an active metabolite of the mastermind-like 1 (MAM-1) chromatin recruitment inhibitor IMR-1 (Item No. 27920).{35889} It binds to the intracellular domain of Notch (Kd = 2.9 µM) and disrupts the protein-protein interactions between Notch and MAM-1 and CFB1, suppressor of Hairless, Lag-1 (CSL) transcription factor. IMR-1A increases multiciliation in primary choroid plexus cancer cells when used at a concentration of 25 µM.{69363}

• Artikelnummer: CAY37432-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37432-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe