Indium (III) thiosemicarbazone 5b, CAS 2345755-20-4

Formulation: A solid

Formal Name: (OC-6-43)-dichloro[N,N-dimethyl-2-[(2-pyridinyl-κN)methylene]hydrazinecarbothioamide-κN2,κS]methoxy-indium

Purity: ≥95%

Formula Markup: C10H15Cl2InN4OS

Formula Weight: 425

Shelf life (days): 730

CAS Number: 2345755-20-4

Notes: Indium (III) thiosemicarbazone 5b is an anticancer agent.{64158} It is cytotoxic to A549, MCF-7 breast, MCF-7/DDP cisplatin-resistant breast, and Hl 7702 liver cancer cells (IC50s = 2.41, 1.97, 2.11, and 8.95 µM, respectively). Indium (III) thiosemicarbazone 5b decreases PI3K, Akt, mTOR, P-gp, and GSH levels in MCF-7/DDP cells. In vivo, indium (III) thiosemicarbazone 5b (2.5 µmol/kg) reduces tumor weight and volume in an MCF-7/DDP mouse xenograft model. Liposomes containing indium (III) thiosemicarbazone 5b also induce apoptosis and pro-death autophagy in MCF-7/DDP cells, as well as reduce tumor volume and weight in an MCF-7/DDP mouse xenograft model.

• Artikelnummer: CAY35601-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 35601-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK
• Methode: Reinstoffe