Product Description: Indotecan (LMP-400), an indenoisoquinoline derivative, is a potent Topoisomerase I inhibitor, with IC50s of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. Indotecan prevents the relaxation of supercoiled DNA and can be used for the research of visceral leishmaniasis[1][2].
Applications: Neuroscience-Neuromodulation
Formula: C26H26N2O7
References: [1]Balaña-Fouce R, et, al. Indotecan (LMP400) and AM13-55: two novel indenoisoquinolines show potential for treating visceral leishmaniasis. Antimicrob Agents Chemother. 2012 Oct;56(10):5264-70./[2]Seol Y, et, al. Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors. Mol Cancer Ther. 2015 Nov;14(11):2552-9.
CAS Number: 915303-09-2
Molecular Weight: 478.49
Compound Purity: 98.0
Research Area: Cancer; Infection
Solubility: DMSO : 1.23 mg/mL (ultrasonic;adjust pH to 6 with 1 M HCL)
Target: Topoisomerase
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