inS3-54-A18, CAS 328998-53-4

Formulation: A solid

Formal Name: 3-[(4-chlorophenyl)methylene]-1,3-dihydro-1-(4-hydroxyphenyl)-5-phenyl-2H-pyrrol-2-one

Purity: ≥98%

Formula Markup: C23H16ClNO2

Formula Weight: 373,8

Shelf life (days): 1460

CAS Number: 328998-53-4

Notes: inS3-54-A18 is an inhibitor of STAT3.{51546} It selectively inhibits the binding of STAT3 to DNA over STAT1 at 25 µM. inS3-54-A18 (20 µM) inhibits STAT3 activity in a reporter assay using MDA-MB-231 breast cancer cells. It induces apoptosis in, and reduces migration and invasion of, A549 non-small cell lung cancer (NSCLC) and MDA-MB-231 cells when used at concentrations of 5 or 10 µM. inS3-54-A18 (200 mg/kg) reduces tumor volume in an A549 mouse xenograft model.

• Artikelnummer: CAY39678-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39678-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK